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OwnerDidier BOQUET, Amaury HERBET +6inventors
InventorsDidier BOQUET, Amaury HERBET, Narciso COSTA, Marie HAUTIERE, Franck DENAT, Claire BERNHARD, Victor GONCALVES, Delphine VIVIER
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The present invention relates to an antigen-binding mutant antibody fragment comprising a mutated heavy chain variable domain, wherein the amino acid residue at position 128 according to the IMGT nomenclature of the heavy chain variable domain is substituted by a cysteine, provided that this fragment is not a Fab fragment in which the mutated heavy chain fragment corresponds to the amino acid sequence SEQ ID NO: 1 and the light chain fragment corresponds to the amino acid sequence SEQ ID NO: 2. The present invention also relates to nucleic acid molecules, vectors and host cells that can be used for the production of the mutant antibody fragment, final and intermediate conjugates comprising same and methods for the production of same, as well as various uses thereof.
A mutant antibody fragment specifically binding to the endothelin A receptor or endothelin B receptor, comprising a mutated heavy chain variable domain, the amino acid residue at position 128 according to the IMGT nomenclature of the heavy chain variable domain being substituted by a cysteine, provided that said fragment is not a Fab fragment in which the mutated heavy chain fragment corresponds to the amino acid sequence SEQ ID NO:
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Dependencies are inferred from the claim text.