Membrane translocation domains and uses thereof

Abstract

Described are peptides comprising a membrane translocation domain having one or more cell penetrating peptide motifs, where at least one cell penetrating peptide motif is from 3 to 10 amino acid residues in length and has at least three arginine and/or lysine residues; or where at least one cell penetrating peptide motif is from 3 to 10 amino acid residues in length and has at least two arginine and/or lysine residues and at least one other cell penetrating peptide motif is from 2 to 8 amino acid residues in length and has at least two hydrophobic residues. Compositions comprising a cargo motif bound to the disclosed peptides are also disclosed. Also disclosed are methods of delivering a cargo moiety into a cell comprising contacting the cell with the peptide as disclosed herein.

Dependencies are inferred from the claim text.