Stapled peptides
AssigneeThe Florey Institute of Neuroscience and Mental Health
InventorsAkhter HOSSAIN, John FURNESS
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Abstract
The present disclosure relates to a peptide comprising two α,α-disubstituted amino acid residues, wherein: the peptide is comprises an α-helix; and the α,α-disubstituted amino acids each comprise as their α-substituents both of: a) an alkyl, cycloalkyl or alkenyl group; and b) an aromatic group capable of π-π stacking with the aromatic group of the other α,α-disubstituted amino acid residue, and wherein the two α,α-disubstituted amino acid residues are located at residue positions such that, in the α-helix, their aromatic groups may engage in π-π stacking with one another.
Claims41
A peptide comprising two α,α-disubstituted amino acid residues, wherein:
- the peptide comprises an α-helix;
- and
- the α,α-disubstituted amino acids each comprise as their α-substituents both of:
- a) an alkyl, cycloalkyl or alkenyl group;
- and;
- b) an aromatic group capable of π-π stacking with the aromatic group of the other α,α-disubstituted amino acid residue,
- and wherein the two α,α-disubstituted amino acid residues are located at residue positions such that, in the α-helix, their aromatic groups may engage in π-π stacking with one another.
Dependencies are inferred from the claim text.