Process for preparation of dual gip/glp-1 peptides having controlled particle size
AssigneeAssia Chemical Industries Ltd.
InventorsOffir Barel, Abed Masarwa, Polina Lapido
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Abstract
The present disclosure relates to processes for preparation of a peptide powder, and the preparation of peptide particles, for example a Dual GIP/GLP-1 peptide such as Tirzepatide. More specifically, the disclosure relates to a process comprising lyophilizing a solution comprising the peptide; and particle size reduction of the obtained lyophilizate. The disclosure further relates to Dual GIP/GLP-1 peptides, particularly Tirzepatide, obtainable by said process and its use in medicine and cosmetic treatment.
Claims35
A process for preparation of a peptide powder wherein the process comprises:
- a) providing a solution comprising one or more solvents and a peptide, wherein the concentration (w/w) of the peptide is:
- not less than about 2.5% or from about 2.5% (w/w) to about 20% (w/w);
- wherein the solution has a pH of:
- about 5 to about 10, about 6 to about 9 or about 7 to about 8.5;
- and b) lyophilizing the solution.
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Dependencies are inferred from the claim text.