Antigenic Multimeric Respiratory Syncytial Virus Polypeptides
AssigneeSanofi
InventorsKurt Swanson, Chih-Jen Wei, Gary J. Nabel
Life of this patent
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Abstract
This disclosure relates to antigenic multimeric respiratory syncytial virus (RSV) G polypeptides for use in eliciting an immune response to RSV.
Claims43
An antigenic RSV G polypeptide comprising more than two RSV G central conserved region (Gcc) monomers and a multimerization domain, wherein the polypeptide does not comprise ferritin and/or the polypeptide is a single chain polypeptide,
- wherein the more than two RSV Gcc monomers comprise RSV Gcc monomers of strain A or strain B,
- wherein the RSV Gcc of strain A comprises:
- a) the same sequence of amino acids as amino acids 2-42 of SEO ID NO:
- 4, or
- b) the same sequence of amino acids as amino acids 151-193 of SEO ID NO:
- 1;
- wherein the RSV Gcc of strain B comprises the same sequence of amino acids as amino acids 10-51 of SEO ID NO:
- 8;
- and
- wherein the multimerization domain comprises the sequence of SEO ID NOs:
- 9, 11, or 13.
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Dependencies are inferred from the claim text.