Peptide inhibitors of focal adhesion kinase activity and uses thereof
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsTimothy Marlowe, Warren S. Weiner
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Abstract
This disclosure provides peptides which have an affinity for the focal adhesion targeting (FAT) domain of focal adhesion kinase (FAK). In particular, the peptides are modified and derived from the sequence of the LD2 alpha helical domain of paxillin (e.g., LD2 peptides), the LD4 domain of paxillin (e.g., LD4 peptides), and CD8 peptides. These peptides are capable of blocking an interaction between paxillin and FAK, thereby inhibiting FAK activity related to FAK-paxillin interaction. The invention further provides uses for such peptides as therapeutics for the treatment of cancer and other diseases characterized with FAK activity and/or expression (e.g., fibrosis).
Claims1
A compound having Formula I:
- including pharmaceutically acceptable salts, solvates, and/or prodrugs thereof;
- wherein YC, YT, Z1, R1, L1, Q1, R2, and Z2 independently include any chemical moiety that permits the resulting compound to bind with the FAT domain of FAK and inhibit FAK's interaction with a paxillin protein.
Dependencies are inferred from the claim text.