Peptide substrates and inhibitors of cathepsin b

Abstract

Pharmaceutical compositions comprising a peptidic inhibitor of cathepsin B. Methods for inhibiting neutral pH cathepsin B activity, comprising administering to a subject in need an effective amount of a peptidic inhibitor of cathepsin B, such a Z-Nle-Lys-Arg-AMC. Methods for treatment or prevention of a disease comprising administering to a subject in need an effective amount of a peptidic inhibitor of cathepsin B. Methods of diagnostic observation, research tools and methods of use in drug development are also included.

Dependencies are inferred from the claim text.