Substituted 2,3-dihydrobenzo[d][1,3]oxaphosphole ligand, preparation method and use thereof

A substituted 2,3-dihydrobenzo[d][1,3]oxaphosphole ligand, characterised in that it is represented by the structure of formula (I),

• wherein R4 is hydrogen, alkyl, alkenyl, cycloalkyl, heterocyclyl, alkyl-OC(═O)—, alkyl-C(═O)O—, dialkylphospho, diarylphospho, di(3,5-dimethyl-4-methoxyphenyl)phospho, di(3,5-di-tert-butyl-4-methoxyphenyl)phospho, dicycloalkylphospho, dialkoxyphospho, diaryloxyphospho, dicycloalkyloxyphospho, dialkylphospho(═O)—, diarylphospho(═O)—, dicycloalkylphospho(═O)—, dialkoxyphospho(═O)—, diaryloxyphospho(═O)—, dicycloalkyloxyphospho(═O)—, ferrocene, aryl, heteroaryl, alkyloxy, cycloalkyloxy, heterocyclyloxy, aryloxy, heteroaryloxy, cycloalkylalkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl;
• alternatively, R4 and R5, together with the carbon atom to which they are attached, form a cycloalkyl or heterocyclyl group;
• alternatively, R4 and the adjacent R6, together with the carbon atoms to which they are attached, form a cycloalkyl or heterocyclyl group;
• X1 is N or CRX1;
• X2 is N or CRX2;
• each of RX1 and RX2 is independently hydrogen, amino, hydroxy, alkyl-NH—, (alkyl)2N—, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyloxy, cycloalkyloxy, heterocyclyloxy, aryloxy, heteroaryloxy, —SO2NMe2 or halo;
• is ═O or ═S;
• or
• is absent;
• R1 is hydrogen, alkyl, aryl, heteroaryl, alkyloxy, —SO2NMe2 or halo;
• R2 is hydrogen, alkyl, aryl, heteroaryl, alkyloxy, —SO2NMe2 or halo;
• or R1 and R2, together with the carbon atoms to which they are attached, form an aryl or heteroaryl group;
• R3 is hydrogen, alkyl, cycloalkyl, aryl, heteroaryl or alkyloxy;
• R5 is hydrogen, alkyl, aryl, heteroaryl or alkyloxy;
• R6 is hydrogen;
• n is 0 or 1;
• or R4 is
• wherein X1a is N or CRX1a, X2a is N or CRX2a;
• each of RX1a and RX2a is independently hydrogen, amino, hydroxy, alkyl-NH—, (alkyl)2N—, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyloxy, cycloalkyloxy, heterocyclyloxy, aryloxy, heteroaryloxy, fluoro, chloro, bromo or iodo;
• is ═O or ═S;
• or
• is absent;
• Z is a bond, cycloalkylene, heterocyclylene, arylene, heteroarylene, alkylene or
• R1a is hydrogen, alkyl, aryl, heteroaryl, alkyloxy or halo;
• R2a is hydrogen, alkyl, aryl, heteroaryl, alkyloxy or halo;
• or R1a and R2a, together with the carbon atoms to which they are attached, form an aryl or heteroaryl group;
• R3a is hydrogen, alkyl, cycloalkyl, aryl, heteroaryl or alkyloxy;
• R5a is hydrogen, alkyl, aryl, heteroaryl or alkyloxy;
• m is 0 or 1;
• the alkyl, alkenyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, cycloalkylene, heterocyclylene, arylene, heteroarylene and alkylene mentioned in the single groups or complex groups hereinabove are each independently optionally substituted with 1, 2, 3, 4 or 5 substituents selected from hydroxy, amino, halo, carboxyl, sulfonyl, alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyloxy, alkylthio, cycloalkyloxy, heterocyclyloxy, aryloxy, heteroaryloxy, alkyl-NH—, (alkyl)2N—, alkyl-OC(═O)—, alkyl-C(═O)O—, dialkylphospho, diarylphospho, di(3,5-dimethyl-4-methoxyphenyl)phospho, di(3,5-di-tert-butyl-4-methoxyphenyl)phospho, dicycloalkylphospho, dialkoxyphospho, diaryloxyphospho, dicycloalkyloxyphospho, dialkylphospho(═O)—, diarylphospho(═O)—, dicycloalkylphospho(═O)—, dialkoxyphospho(═O)—, diaryloxyphospho(═O) and dicycloalkyloxyphospho(═O)—.