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US 2026/0265280 A1Published application
Prevention/Treatment of Ischemic Reperfusion Injury
OwnerYoshi Satoh, Kurt Jarnagin +4inventors
InventorsYoshi Satoh, Kurt Jarnagin, Huisheng Xu, Xiaohu Zhang, Ning Jia, Elizabeth Squiers
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Abstract
This invention provides, among other things, compounds useful for treating and/or preventing an injury before, during, or after a surgical procedure.
Claims34
A compound, or a salt or a tautomer or an isomer thereof, having a structure according to formula (I) or (II):
- wherein
- R1, when present, is C(O)Ra or substituted or unsubstituted C1-6 alkylene
- wherein Ra is substituted or unsubstituted C1-6 alkoxy or substituted or unsubstituted C1-6 alkylamino
- R2 is H or C(O)Rb or substituted or unsubstituted phosphate
- wherein Rb is substituted or unsubstituted C1-6 alkyl or substituted or unsubstituted C1-6 alkoxy or substituted or unsubstituted C1-6 alkylamino
- with the proviso that the compound is not
3 more elements
A method of treating and/or preventing ischemic reperfusion injury before, during, or after a surgical procedure to a kidney of a subject, comprising:
- administering to the subject a therapeutically and/or prophylactically effective amount of a compound having a structure which is:
- or a salt or a tautomer or an isomer thereof, thereby treating and/or preventing the ischemic reperfusion injury before, during, or after the surgical procedure to the kidney of the subject.
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Dependencies are inferred from the claim text.