Back to results
US 2026/0265278 A1Published application
Processes of preparing psilocin and psilocybin
OwnerMatthew Alexander James Duncton, Roy SWARINGENinventors
Life of this patent
Estimating the term…
Abstract
Described herein are processes for preparing psilocin and psilocybin and chemical intermediates used in the synthetic processes.
Claims126
A process of preparing Compound 1:
- comprising (a-iii) contacting Compound D:
- with a formaldehyde in the presence of a reducing agent, or with iodomethane in the presence of a base.
A process of preparing Compound 1:
- comprising (a) contacting Compound G:
- with a formaldehyde in the presence of a reducing agent, wherein R is hydrogen, acetyl, or benzyl.
A process of preparing Compound 1:
- comprising (a) contacting Compound H:
- with Mannich salt Me2N+═CH2 X− in the presence of a base, wherein X is I, Cl or CF3CO2, R is acetyl or methoxymethyl (MOM), and PG is a protecting group;
- (b) removing the protecting group in Compound J:
A process of preparing Compound 1:
- comprising (a) contacting Compound K:
- with a 1,1-dimethylaziridinium compound;
- and
- (b) contacting Compound L:
- with a base in the presence of a solvent.
2 more elements
A process of preparing Compound 1:
- comprising (a) contacting Compound K:
- with aziridinium tetrafluoroborate
- and
- (b) contacting Compound M:
- with a formaldehyde in the presence of a reducing agent, or with iodomethane in the presence of a first base;
- and
- (c) contacting Compound L:
- with a second base in the presence of a solvent.
5 more elements
A process of preparing Compound 1:
- comprising (a) contacting Compound K:
- with a cyclic sulfamidate in the presence of a metal base;
- and
- (b) contacting Compound M:
- with a formaldehyde in the presence of a reducing agent, or with iodomethane in the presence of a first base;
- and
- (c) contacting Compound L:
- with a second base in the presence of a solvent.
5 more elements
A process of preparing Compound 2:
- comprising (a) contacting Compound K:
- with 2-(dimethylamino)acetaldehyde or its derivative in the presence of a catalyst;
- and
- (b) contacting Compound M:
- with POCl3 in a solvent;
- wherein R is hydrogen or acetyl.
3 more elements
A process of preparing Compound 1:
- comprising (a) contacting Compound E:
- with 2-(dimethylamino)ethanol in the presence of a first catalyst and a first base, wherein R is hydrogen, acetyl, or benzyl;
- and
- (b) contacting Compound N:
- with hydrogen gas in the presence of a second catalyst, or with a second base.
2 more elements
A process of preparing Compound 1:
- comprising (a) contacting Compound E:
- with chloroacetaldehyde and Me2NH in the presence of an acid, wherein R is hydrogen, acetyl, or benzyl;
- and
- (b) contacting Compound 0:
- with a reducing agent.
2 more elements
Dependencies are inferred from the claim text.