Novel compounds with mtorc2-inhibitory activity and uses thereof

A compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof.

• wherein in Chemical Formula 1,
• the “X” is O, S, or CH2,
• the “R1” is hydrogen, halo (F, Br, Cl, or I), a substituted or unsubstituted C6-10 aryl, or a substituted or unsubstituted 4 to 12-membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O, and S,
• the “R2” is hydrogen, halo (F, Br, Cl, or I), a substituted or unsubstituted C6-10 aryl, a substituted or unsubstituted C1-6 amino, a substituted or unsubstituted 4 to 12-membered heterocycloalkyl, or an unsubstituted benzylamino,
• the “R3” is hydrogen or halo (F, Br, Cl, or I),
• the “R4” and “R5” are each independently an unsubstituted C1-6 alkoxy, or “R4” and “R5” together with two oxygen atoms to which they are attached may form —O(CH)nO— (wherein n is 1 or 2),
• the substituted aryl or the substituted heteroaryl may be substituted with one or more substituents selected from the group consisting of hydroxy (OH), halo (F, Br, Cl, or I), a C1-10 linear or branched alkyl which is substituted or unsubstituted with 1 to 3 halo, and an unsubstituted C1-5 linear or branched alkoxy,
• the substituted amino may be substituted with one or more substituents selected from the group consisting of a C1-5 linear or branched alkyl, an unsubstituted C3-8 cycloalkyl, a C1-5 linear alkyl which is substituted with a phenyl group substituted with a C1-5 linear or branched alkoxy, a C1-5 linear alkyl which is substituted with an unsubstituted thiophenyl group, a C3-8 cycloalkyl and a sulfonyl which is substituted with a C1-5 linear alkyl,
• the substituted heterocycloalkyl may be substituted with an unsubstituted C6-10 aryl, or an unsubstituted C6-10 aryl C1-6 alkyl, and
• the compound of Chemical Formula 1 does not include the following compounds:
• a) 2,3-dimethoxydibenz[b,e]oxepin-11(6H)-one;
• and
• b) 9-bromo[2]benzoxepino[3,4-f]-1,3-benzodioxol-11(6H)-one.