Spirocyclic linked tricyclic compounds

A compound of Formula (I)

• or a pharmaceutically acceptable salt thereof, wherein:
• Z1, Z2, or Z3 are each independently CH2, CH, N, or NH provided that at least one of Z1, Z2, or Z3 is N or NH, and
• (i) the dashed bond between Z1 and Z2 is a double bond, and the dashed bond between Z2 and Z3 is a single bond, or
• (ii) the dashed bond between Z2 and Z3 is a double bond, and the dashed bond between Z1 and Z2 is a single bond;
• Y1 is CRY1 or N;
• RY1 is H or halo;
• Y2 is CRY2 or N;
• RY2 is H or halo;
• dashed bond a is absent or a bond;
• R1 is C3-12 cycloalkyl, heterocycloalkyl, C6-12 aryl, or heteroaryl, wherein each heterocycloalkyl has 3 to 12 ring members and 1 to 4 heteroatoms each independently N, O, or S, each heteroaryl has 5 to 10 ring members and 1 to 4 heteroatoms each independently N, O, or S, and wherein R1 is substituted with 0, 1, 2, or 3 Ria;
• each R1a is independently C1-6 alkyl, C1-6 alkoxy, halo, C1-6 haloalkyl, or C1-6 haloalkoxy;
• the moiety Z— is a single bond, —C(O)—, —NRxa, NRxa—NRxb—S(O)2—, ═N—NRxb—S(O)2—, —NRxa—S(O)2—, —N═S(CH3)(O)—, —O—, —S(O)2—, or —S(O)2—NRxa—, provided that when the moiety N— is ═N—NRxb—S(O)2—, then dashed bond a is absent;
• Rxa and Rxb are each independently H, C1-4 alkyl, or —C1-4 alkyl-OH;
• R2 is C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C3-12 cycloalkyl, heterocycloalkyl, C6-12 aryl, or heteroaryl, wherein each heterocycloalkyl has 3 to 12 ring members and 1 to 4 heteroatoms each independently N, O, S, or S(O)2, each heteroaryl has 5 to 10 ring members and 1 to 4 heteroatoms each independently N, O, or S, and wherein the C3-12 cycloalkyl, heterocycloalkyl, C6-12 aryl, and heteroaryl are substituted with 0, 1, 2, 3, 4, or 5 R2a;
• each R2a is independently C1-6 alkyl, —CN, —N(R2a2)2, —OH, C1-6 alkoxy, halo, C1-6 haloalkyl, C1-6 haloalkoxy, oxo, —C(O)N(R2a2)2, —C(O)OR2a2, —N(R2a1)C(O)R2a2, N(R2a1)C(O)N(R2a2)2, —NO2, —N(R2a1)S(O)2R2a2, —N(R2a1)S(O)2N(R2a2)2, —N═S(O)(R2a2)2, —S(═NR2a1)(O)(R2a2), —S(O)2R2a2, —S(O)2N(R2a2)2, C3-6 cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein each heterocycloalkyl has 3 to 6 ring members and 1 to 3 heteroatoms each independently N, O, S, or S(O)2, each heteroaryl has 5 to 6 ring members and 1 to 3 heteroatoms each independently N, O, or S, and wherein each C3-6 cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is substituted with 0, 1, 2, or 3 R23, each C1-6 alkyl is substituted with 0, 1, 2, or 3 R2a4, and each C1-6 alkoxy is substituted with 0, 1, 2, or 3 R2a5;
• alternatively, two R2a groups on adjacent ring vertices combine to form a C3-6 cycloalkyl or a heterocycloalkyl having 3 to 6 ring members and 1 to 3 heteroatoms each independently N, O, or S, wherein the C3-6 cycloalkyl and heterocycloalkyl are substituted with 0, 1, or 2 R2a3;
• each R2a1 and R2a2 is independently H, C1-6 alkyl, C1-6 haloalkyl, or heterocycloalkyl having 3 to 6 ring members and 1 to 3 heteroatoms each independently N, O, or S;
• each R2a3 is independently C1-6 alkyl, halo, C1-6 haloalkyl, or —C(O)OH;
• each R2a4 is independently —N(R2a2)2, —CN, —OH, C1-6 alkoxy, C1-6 haloalkoxy, —C(O)N(R2a2)2, —C(O)OR2a2, —N(R2a1)C(O)R2a2, —N(R2a1)S(O)2R2a2, —N═S(O)(R2a2)2, —S(═NR2a1)(O)(R2a2), —S(O)2R2a2, or —S(O)2N(R2a2)2;
• each R2a5 is independently —OH, C1-6 alkoxy, C1-6 haloalkoxy, —C(O)N(R2a2)2, —C(O)OR2a2, or
• —N(R2a1)C(O)R2a2;
• Ring B is a C3-12 cycloalkyl or heterocycloalkyl having 3 to 12 ring members and 1 to 4 heteroatoms each independently N, O, or S, wherein the C3-12 cycloalkyl and heterocycloalkyl are substituted with 0, 1, 2, or 3 RB;
• each RB is independently C1-6 alkyl, —CN, —NRB1RB2, —ORB1, halo, or C1-6 haloalkyl;
• and
• each RB1 and RB2 is independently H, C1-6 alkyl, or C1-6 haloalkyl.