Fabk inhibitor compositions

A compound having the structure:

• wherein:
• X is S, N or O;
• R1 is —CF3, —CH3, —SO2CH3, halogen, —OCH3, —OCOCH3, —OC2H5 or —SO2N(CH3)2;
• Z, when present, is NH, NHCO or NHCONH;
• Y is S or N;
• and
• R2 is a halogen, —OCH3, —CF3, —CN or —OCF3.

A compound having the structure:

• wherein:
• D is a benzene, pyridine, pyrimidine, benzothiazole, or quinoline;
• and
• R1 and R2 are a halogen, —OCH3, —CF3, —CN or —OCF3.

A compound selected from the group consisting of:

• C19H16N6OS2 (Compound A);
• C19H15BrN6OS2 (Compound B);
• C16H14N4OS2 (Compound C);
• C19H15FN6OS2 (Compound D);
• C20H18N6O2S2 (Compound E);
• C20H15F3N6OS2 (Compound F);
• C20H15F3N6O2S2 (Compound G);
• C20H15N7OS2 (Compound H);
• C19H16N6O2S2 (Compound I);
• C21H18N6O4S2 (Compound J);
• C19H17N6O5PS2 (Compound K);
• C30H34N8O3S2 (Compound L);
• C23H20N6O6S2 (Compound M);
• C25H22N6O8S2 (Compound N);
• C17H14N6OS3 (Compound O);
• C19H15BrN6S3 (Compound P);
• (C20H15Br2N5OS2 (Compound Q);
• C21H15BrN6OS3 (Compound R);
• C17H14N6OS2 (Compound S);
• C18H15N7OS2 (Compound T);
• C18H14N6O2S2 (Compound U);
• C18H14BrN7OS2 (Compound V);
• C23H17BrN6OS2 (Compound W);
• C19H14BrClN6OS2 (Compound X);
• C20H14BrF3N6OS2 (Compound Y);
• C20H14BrF3N6OS2 (Compound Z);
• C20H16BrN5OS2 (Compound AA);
• C21H18BrN5O2S2 (Compound AB);
• C20H15BrClN5OS2 (Compound AC);
• C18H14N4O3S2 (Compound AD);
• C16H12N4OS2 (Compound AE);
• C15H14N4O3S2 (Compound AF);
• C17H16N4O4S2 (Compound AG);
• C18H18N4O3S2 (Compound AH);
• C17H16N2O5S3 (Compound AI);
• C20H13ClN2O5S2 (Compound AJ);
• C17H13N3O3S (Compound AK);
• C14H10N6OS2 (Compound AL);
• C18H13N3O5S2 (Compound AM);
• C18H16N2O5S2 (Compound AN);
• C20H23N5O3S (Compound AO);
• C18H18N4O4S2 (Compound AP);
• C16H13ClN2O3S3 (Compound AQ);
• C17H14N4O3S3 (Compound AR);
• C18H16N6O3S (Compound AS);
• C19H15ClN4O2S (Compound AT);
• C17H12ClN3O2S3 (Compound AU);
• C16H14N4O4S2 (Compound AV);
• C18H20N4O3S2 (Compound AW);
• C14H14N4O2S3 (Compound AX);
• C16H14N4O4S2 (Compound AY);
• C21H16N4O5S2 (Compound AZ);
• C18H13N3O4S2 (Compound BA);
• C13H12N4O3S3 (Compound BB);
• C22H19N3O4S2 (Compound BC);
• C17H14N4O3S2 (Compound BD);
• C17H16N2O3S2 (Compound BE);
• C17H16N2O3S3 (Compound BF);
• C20H15ClN4O4S3 (Compound BG);
• C16H12N4OS2 (Compound BH);
• C16H12N4O3S3 (Compound BI);
• C17H14N6O3S3 (Compound BJ);
• C18H16N6O4S2 (Compound BK);
• C17H13BrN6O3S2 (Compound BL);
• C17H13ClN6O3S2 (Compound BM);
• C17H14N6O3S2 (Compound BN);
• C18H15N5O3S2 (Compound BO);
• C18H15N5O3S2 (Compound BP);
• C18H14BrN5OS (Compound BQ);
• C18H13BrFN5OS (Compound BR);
• C18H13Br2N5OS (Compound BS);
• C19H13BrF3N5OS (Compound BT);
• C18H12BrF2N5OS (Compound BU);
• C18H14N4O2S (Compound BV);
• C19H16BrN5O3S2 (Compound BW);
• C18H13BrClN5OS (Compound BX);
• C20H18BrN5O2S (Compound BY);
• C18H23BrN4OS (Compound BZ);
• C19H13BrF3N5O2S (Compound CA);
• C19H13BrF3N5OS (Compound CB);
• C19H13BrF3N5OS (Compound CC);
• C19H13BrF3N5OS (Compound CD);
• C14H10F3N3O3S3 (Compound CE);
• C17H13N3O4S3 (Compound CF);
• C17H13N3O3S4 (Compound CG);
• C18H19N5O2S2 (Compound CH);
• C19H15N5O2S2 (Compound CI);
• C21H15ClN4O2S2 (Compound CJ);
• C14H12N4O2S2 (Compound CK);
• C19H16N4OS2 (Compound CL);
• C18H16N6OS2 (Compound CM);
• C19H13ClN4O2S2 (Compound CN);
• C17H12N6O2S2 (Compound CO);
• C17H12N6O2S2 (Compound CP);
• C18H14N4OS2 (Compound CQ);
• C19H13ClN4O2S2 (Compound CR);
• C17H12N4O3S2 (Compound CS);
• C19H14ClN5O2S2 (Compound CT);
• C20H16N4O3S2 (Compound CU);
• C18H19N3O3S2 (Compound CV);
• C18H18N2O5S2 (Compound CW);
• C20H21ClN4O2S (Compound CX);
• C18H16F3N3O3S (Compound CY);
• C18H19N3O5S2 (Compound CZ;
• C20H21FN4O2S (Compound DA);
• C20H22N4O2S (Compound DB);
• C18H14ClN5OS2 (Compound DC);
• C20H15F3N4OS2 (Compound DD);
• C20H18N4O3S2 (Compound DE);
• C20H17FN4O2S2 (Compound DF);
• C20H15ClN4O2S2 (Compound DG);
• C20H17ClN4O2S2 (Compound DH);
• C21H17F3N4O2S2 (Compound DI);
• C20H16ClN5O2S2 (Compound DJ);
• C20H18N4O2S2 (Compound DK);
• C20H15F3N4O2S2 (Compound DL);
• C19H15N3OS2 (Compound DM);
• C20H17N3OS2 (Compound DN);
• C20H17N3OS2 (Compound DO);
• C21H19N3O2S2 (Compound DP);
• C20H17N3OS2 (Compound DQ);
• C20H17N3O2S2 (Compound DR);
• C22H21N3OS2 (Compound DS);
• C21H19N3OS2 (Compound DT);
• C22H16F3N3O2S (Compound DU);
• C22H16F3N3OS (Compound DV);
• C19H18F3N3O3S (Compound DW);
• C22H19N3O4S2 (Compound DX);
• C22H19N3O3S2 (Compound DY);
• C19H16N4O3S3 (Compound DZ);
• C21H18ClN5O3S2 (Compound EA);
• C20H16ClN5O2S2 (Compound EB);
• C19H14ClN5O2S2 (Compound EC);
• C20H16ClN5O2S2 (Compound ED);
• C19H21N3O5S2 (Compound EE);
• C19H18F3N3O4S (Compound EF);
• C18H16F3N3O4S (Compound EG);
• C22H16F3N3OS (Compound EH);
• C22H16F3N3O2S (Compound EL);
• C23H18F3N3O2S (Compound EJ);
• C22H19N3O4S2 (Compound EK);
• C17H18N4O3S2 (Compound EL);
• C12H10N4OS2 (Compound EM);
• C19H13FN4O2S2 (Compound EN);
• C18H20N4O5S3 (Compound EO);
• C13H12N4O3S3 (Compound EP);
• C19H20N4O5S3 (Compound EQ);
• C17H14F3N3O4S2 (Compound ER);
• C16H14ClN3O3S2(Compound ES);
• C14H14N4O3S3 (Compound ET);
• C19H17N5O3S2 (Compound EU);
• C16H14BrN3O3S2 (Compound EV);
• C18H15N3O3S2 (Compound EW);
• C19H21N5O4S3 (Compound EX);
• C20H16N4O4S3 (Compound EY);
• C19H16N4O3S3 (Compound EZ);
• C18H16N4O3S2 (Compound FA);
• C20H23N3O3S2 (Compound FB);
• C18H14FN3O3S2 (Compound FC);
• C17H13N5O4S4 (Compound FD);
• C17H15FN4O4S3 (Compound FE);
• C21H15F3N4O5S3 (Compound FF);
• C18H15N5OS (Compound FG);
• C18H16N4O3S2 (Compound FH);
• C21H18N4O5S3 (Compound FL);
• C21H15F3N4O4S3 (Compound FJ);
• C20H18N4O3S2 (Compound FK);
• C17H14N6O3S3 (Compound FL);
• C21H18N4O4S3 (Compound FM);
• C19H16N4O3S3 (Compound FN);
• C20H14Cl2N4O4S3 (Compound FO);
• C14H13N3O3S3 (Compound FP);
• C17H15N5O3S2 (Compound FQ);
• C18H16N4O3S2 (Compound FR);
• C18H15N3O3S3 (Compound FS);
• C20H15ClN4O4S3 (Compound FT);
• C19H16BrN5O3S2 (Compound FU);
• C19H16N4O3S2 (Compound FV);
• C22H19N3O3S2 (Compound FW);
• C19H21N3O5S2 (Compound FX);
• C19H16N4OS2 (Compound FY);
• C20H17ClN4O2S2 (Compound FZ);
• C20H18N4O2S2 (Compound GA);
• C19H15ClN4OS2 (Compound GB);
• C18H14ClN5OS2 (Compound GC);
• C18H13ClN4OS2 (Compound GD);
• C19H15ClN4OS2 (Compound GE);
• C19H16N4OS2 (Compound GF);
• C18H14N4OS (Compound GH);
• C18H13BrN4OS (Compound GI);
• C19H16N4O2S (Compound GJ);
• C17H19N5O3S (Compound GK);
• C12H11N5OS (Compound GL);
• C19H17N5OS (Compound GM);
• C18H16N6O (Compound GN);
• C19H19F3N4O3 (Compound GO);
• C18H17F3N4O3 (Compound GP);
• C18H14ClN5OS (Compound GQ);
• C19H18F3N3O4 (Compound GR);
• C18H16F3N3O4 (Compound GS);
• C17H18N4O4S (Compound GT);
• C12H10N4O2S (Compound GU);
• C18H15N5O2 (Compound GV);
• C16H12N4O2S (Compound GW);
• and C14H16ClN3O4S2 (Compound GX).