Benzothiophene derivatives as rxfp1 agonists

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• X1 and X2 are each N or CR1;
• provided that X1 and X2 are not both N;
• R1 is H, halo, C1-4 alkyl substituted with 0-5 halo, or C3-6 cycloalkyl;
• R2 is phenyl substituted with 1-3 R3 and 1 R5, or a 5 to 6-membered heteroaryl comprising 1-4 heteroatoms selected from O, S(═O)p, N, and NR2a and substituted with 0-3 R3 and 0-1 R5;
• R2a is H or C1-3 alkyl substituted with 0-2 halo or —OH;
• R3 is halo, CN, OH, C1-4 alkyl, or —OC1-4 alkyl substituted with 0-5 halo, OH, —OC1-4 alkyl, aryl, or heterocyclyl;
• R4 is C1-6 alkyl substituted with 0-5 halo, CN, OH, or OC1-3 alkyl, —(CRdRd)0-1—C3-10-cycloalkyl substituted with 0-2 R4a or 0-2 R4b, phenyl substituted with 0-2 R4a or 0-2 R4b, —(CRdRd)n-3 to 12-membered heterocyclyl comprising 1-4 heteroatoms selected from O, S(═O)p, N, NH, and NC1-3 alkyl, and substituted with 0-2 R4a or 0-2 R4b;
• R4a or R4b is halo, CN, or C1-4 alkyl substituted with 0-5 halo, OH, or —OC1-4 alkyl substituted with 0-5 halo;
• R5 is —NR5aR5a, —(CH2)1-2—NR5bR5b, —C(═O)NR5bR5b, —S(═O)pNR5bR5b, C3-6 alkyl substituted with 0-2 OH, C2-s alkenyl substituted with 0-3 R6 and 0-2 R7, C2-8 alkynyl substituted with 0-3 R6 and 0-2 R7, C3-12 carbocyclyl substituted with 0-3 R6 and 0-2 R7, or a 3- to 12-membered heterocyclyl comprising 1-4 heteroatoms selected from O, S(═O)p, N and NR10 and substituted with 0-3 R6 and 0-1 R7;
• R5a and R5a together with the nitrogen atom to which they are both attached form a heterocyclyl comprising additional 0-5 heteroatoms selected from O, S(═O)p, N, and NR10, and substituted with 0-3 R6 and 0-2 R7;
• R5b is H or C1-6 alkyl substituted with 0-3 R6 and 0-2 R7;
• or R5b and R5b together with the nitrogen atom to which they are both attached form a heterocyclyl comprising additional 0-5 heteroatoms selected from O, S(═O)p, N, and NR10, and substituted with 0-3 R6 and 0-2 R7;
• R6 is halo, CN, ═O, —OH, —OC1-4 alkyl, or C1-4 alkyl substituted with 0-2 halo or OH;
• R7 is C1-6 alkyl substituted with 0-1 R8 and 0-1 R9, —ORb, —NRaRa, —NRaC(═O)Rb, —NRaC(═O)ORb, —NRaC(═O)NRaRa, —NRaS(═O)pRc, —C(═O)Rb, —C(═O)ORb, —C(═O)NRaRa, —C(═O)NRaS(═O)pRc, —OC(═O)Rb, —S(═O)pRc, —S(═O)pNRaRa, —C(═O)NRaS(═O)pRe, C3-6 carbocyclyl substituted with 0-5 Re, or a 4- to 6-membered heterocyclyl comprising 1-4 heteroatoms selected from O, S(═O)p, N and NRd, and substituted with 0-5 Re;
• R8 is halo, —C(═O)ORb, —C(═O)NRaRa, —C(═O)NRaORb, or C1-4 alkyl substituted with 0-3 halo or OH;
• R9 is —ORb, —NRaRa, —NRaC(═O)Rb, —NRaC(═O)ORb, —NRaC(═O)NRaRa, —NRaS(═O)pRc, —NRaS(═O)pNRaRa, —OC(═O)NRaRa, —OC(═O)NRaORb, —S(═O)pNRaRa, —S(═O)pRe, or —OP(═O)(OH)2, —(CH2)n—C3-6 carbocyclyl substituted with 0-3 Re, or —(CH2)n-heterocyclyl comprising 1-4 heteroatoms selected from O, S(═O)p, and N, and substituted with 0-3 Re;
• R10 is H, C1-4 alkyl substituted with 0-2 R11, —C(═O)Rb, —C(═O)ORb, —C(═O)NRaRa, —C(═O)C(═O)ORb, —S(═O)pRe, C3-6 carbocyclyl substituted with 0-5 Re, or a 4- to 6-membered heterocyclyl comprising 1-4 heteroatoms selected from O, S(═O)p, N and NR12 and substituted with 0-5 Re;
• R11 is —ORb, —C(═O)ORb, —C(═O)NRaRa, —S(═O)pRe, or aryl;
• R12 is H, C1-4 alkyl, or aryl;
• Ra is H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)n—C3-10 carbocyclyl substituted with 0-5 Re, or —(CH2)n-heterocyclyl substituted with 0-5 Re;
• or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclyl substituted with 0-5 Re;
• Rb is H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)n—C3-10carbocyclyl substituted with 0-5 Re, or —(CH2)n-heterocyclyl substituted with 0-5 Re;
• Rc is C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 R, C2-6 alkynyl substituted with 0-5 Re, C3-6 carbocyclyl, or heterocyclyl;
• Rd is H or C1-4 alkyl;
• Re is halo, CN, NO2, ═O, C1-6 alkyl substituted with 0-5 R9, C2-6 alkenyl substituted with 0-5 R9, C2-6 alkynyl substituted with 0-5 Rg, —(CH2)n-carbocyclyl substituted with 0-5 Rg, —(CH2)n-heterocyclyl substituted with 0-5 R9, —(CH2)nORf, —C(═O)ORf, —C(═O)NRfRf, —NRC(═O)Rf, —S(═O)pRf, —S(═O)pNRfRf, —NRfS(═O)pRf, —NRfC(═O)ORf, —OC(═O)NRfRf, or —(CH2)nNRfRf;
• Rf is H, C1-6 alkyl substituted with 0-1 —OC1-4 alkyl, C3-6 cycloalkyl, aryl, or heterocyclyl;
• or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclyl;
• Rg is halo, CN, OH, S(═O)2C1-3 alkyl, C1-6 alkyl, C3-6 cycloalkyl, or aryl;
• n is zero, 1, 2, or 3;
• and
• p is zero, 1, or 2.