Amide prodrugs and uses thereof

A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof:

• wherein:
• R1 is selected from hydrogen, —OR7, —NR7R8, C1-C6alkyl, C2-C6lkenyl, C2-C6alkynyl, C3-C6cycloalkyl, C2-C6heterocycloalkyl, C1-9heteroaryl, phenyl, and —C1-C6alkyl-phenyl, wherein C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, C2-C9heterocycloalkyl, C1-9heteroaryl, phenyl, and —C1-C6alkyl-phenyl are optionally substituted with one or more groups selected from halogen, C1-C6alkyl, C1-6 haloalkyl, C3-C6cycloalkyl, —CN, —OR10, —N(R10)(R11), and —S(O)2R13;
• R2 is selected from hydrogen, —OR7, —NR7R8, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, C2-C6heterocycloalkyl, C1-9heteroaryl, phenyl, and —C1-C6alkyl-phenyl, wherein C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl, C2-C9heterocycloalkyl, C1-9heteroaryl, phenyl, and —C1-C6alkyl-phenyl are optionally substituted with one or more groups selected from halogen, C1-C6alkyl, C1-6 haloalkyl, C3-C6cycloalkyl, —CN, —OR10, —N(R10)(R11), and —S(O)2R13;
• or R1 and R2 are combined to form a C2-C9heterocycloalkyl optionally substituted with one or more groups selected from halogen, C1-6alkyl, C1-6haloalkyl, —OR10, —N(R10)(R11), and —S(O)2R13;
• R3 is selected from halogen, —CN, C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, —OR10, —SR10, —N(R10)(R11), —C(O)R13, —S(O)2R13, and —S(O)2N(R10)(R11)—, wherein C1-6 alkyl, C2-6alkenyl, and C2-6alkynyl, are optionally substituted with one, two, or three groups selected from halogen, C1-6alkyl, C1-6haloalkyl, —OR10, —N(R10)(R11), and —C(O)OR10;
• each R4 is independently selected from halogen, —CN, C1-6alkyl, C1-6haloalkyl, C2-6 alkenyl, C2-6alkynyl, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, C1-9heteroaryl, —OR10, —SR10, —N(R10)(R11), —C(O)OR10, —OC(O)N(R10)(R11), —N(R12)C(O)N(R10)(R11), —N(R12) C(O)OR13, —N(R12)S(O)2R13, —C(O)R13, —S(O)R13, —OC(O)R13, —C(O)N(R10)(R11), —C(O)C(O)N(R10)(R11), —N(R12)C(O)R13, —S(O)2R13, —S(O)2N(R10)(R11)—, —S(═O)(═NH)N(R10)(R11), —CH2C(O)N(R10)(R11), —CH2N(R12)C(O)R13, —CH2S(O)2R13, and —CH2S(0)2N(R10)(R11), wherein C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, and C1-9 heteroaryl are optionally substituted with one, two, or three groups selected from halogen, C1-6alkyl, C1-6haloalkyl, —OR10, —N(R10)(R11), and —C(O)OR10,
• R5 and R6 are independently selected from hydrogen and C1-C6alkyl;
• each R7 and each R8 are independently selected from hydrogen and C1-C6alkyl;
• R9a and R9b are independently selected from hydrogen, halogen, —CN, C1-6alkyl, C1-6 haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, C1-9heteroaryl, —OR10, —SR10, —N(R10)(R11), wherein C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, and C1-9heteroaryl are optionally substituted with one, two, or three groups selected from halogen, C1-6alkyl, C1-6haloalkyl, —OR10, —N(R10)(R11), and —C(O)OR10;
• each R10 is independently selected from hydrogen, C1-6alkyl, C1-6 haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, —C1-6alkyl-C3-6cycloalkyl, C2-9heterocycloalkyl, —C1-6 alkyl-C2-9heterocycloalkyl, C6-10aryl, —C1-6alkyl-C6-10aryl, C1-9heteroaryl, and —C1-6 alkyl-C1-9heteroaryl, wherein C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, —C1-6 alkyl-C3-6cycloalkyl, C2-9heterocycloalkyl, —C1-6alkyl-C2-9heterocycloalkyl, C6-10aryl, —C1-6alkyl-C6-10aryl, C1-9heteroaryl, and —C1-6alkyl-C1-9heteroaryl are optionally substituted with one, two, or three groups selected from halogen, —CN, hydroxy, C1-6 alkyl, C1-6haloalkyl, C1-6alkoxy, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, and C1-9heteroaryl;
• each R11 is independently selected from hydrogen, C1-6alkyl, and C1-6haloalkyl;
• each R12 is independently selected from hydrogen, C1-6alkyl, and C1-6haloalkyl;
• each R13 is independently selected C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C2-9 heterocycloalkyl, C6-10aryl, and C1-9heteroaryl, wherein C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, and C1-9heteroaryl are optionally substituted with one, two, or three groups selected from halogen, —CN, hydroxy, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, C3-6cycloalkyl, C2-9heterocycloalkyl, C6-10aryl, and C1-9heteroaryl;
• and
• m is 0, 1, 2, or 3.