N-(n-aminoalkyl)phenanthridiunium series of chloride-sensitive fluorophores and methods of use thereof
AssigneeThe General Hospital Corporation
InventorsKieran P. Normoyle, Kevin Staley
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Abstract
Disclosed herein are compounds which are chloride-sensitive fluorophores and methods of manufacture and of use thereof.
Claims33
A novel chloride-sensitive fluorophore composition comprised of a tricyclic phenanthridine base first structure and an alkyl amine second structure appended to nitrogen of the phenanthridine ring as illustrated in FIGS. 2 and 3 of the Specification.
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A conjugate of formula F-L-P wherein:
- F is a heteroaryl;
- L is a linker;
- and
- P is a cap group or a polymer chosen from the group consisting of dextran, mannan, pullulan, hyaluronic acid, hydroxyethyl starch, chondroitin sulphate, heparin, heparin sulphate, polyalkylene glycol, Ficoll, polyvinyl alcohol, amylose, amylopectin, chitosan, cyclodextrin, pectin and carrageenan, or a derivative thereof.
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A conjugate of formula (Ia)
- wherein:
- each R′ and R1 is chosen from hydrogen, halogen, alkyl, and heteroalkyl;
- n is chosen from 1, 2, 3, 4, 5, and 6;
- and
- each Rp independently chosen from alkyl, heteroalkyl, benzyl, and aryl.
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A conjugate of formula (Ib)
- wherein:
- each R′ and R1 is chosen from hydrogen, halogen, alkyl, and heteroalkyl;
- n is chosen from 1, 2, 3, 4, 5, and 6;
- and
- each POLY is independently chosen from a dextran polymer.
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Dependencies are inferred from the claim text.