Compounds for the treatment of hiv
AssigneesThe Trustees of the University of Pennsylvania, Dana-Farber Cancer Institute, Inc.
InventorsAmos B. SMITH, III, Christopher James FRITSCHI, Joseph G. SODROSKI, Navid MADANI, Saumya ANANG, Derek YANG, Hung-Ching CHEN
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Abstract
Compositions and methods for treating HIV using 2-(guanidinomethyl)-6-(aminomethyl)-indolinyl derivatives that sensitize HIV-I infected cells to antibody-dependent cellular cytotoxicity, comprising administering to the mammal in need thereof a compound. The compounds of the disclosure provide viral entry inhibition of JR-FL and other resistant HIV-I strains, host antibody recognition and CoRBS exposure of Env, and kill infected cells through ADCC.
Claims23
A compound of Formula I:
- or stereoisomer thereof, wherein:
- R is C0-6alk-aryl, substituted C0-6alk-aryl, C1-6alkyl, substituted C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, or substituted C2-6alkenyl;
- R1 is F, Cl, or Br;
- R2 is F, Cl, or Br;
- R3 is H or C1-6alkyl;
- and
- R4 is H or C1-6alkyl
- or a pharmaceutically acceptable salt thereof.
(canceled)
(canceled)
A compound that is
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.