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US 2026/0265192 A1Published application
Method for synthesizing bilirubin
AssigneeBilix Co., Ltd.
InventorsMYUNG LIP KIM, SANG HO MA, KI SOO PARK, HEE GOO JUN, DA EUN KIM
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Abstract
In a method of synthesizing bilirubin, a compound represented by Formula 2 is prepared by dimerizing a compound represented by Formula 1 or by coupling a compound represented by Formula 3 and a compound represented by Formula 4, thereby firstly chemically synthesizing bilirubin and PEGylated bilirubin, which are usefully used in a medical product or the like.
Claims8
A method for synthesizing bilirubin, the method comprising:
- preparing a compound represented by Formula 2 by dimerizing a compound represented by Formula 1:
- wherein, R1 and R1′ are each independently hydrogen, an alkyl group having 1 to 12 carbon atoms, an aryl group having 6 to 20 carbon atoms, a heteroaryl group having 2 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, or a heteroarylalkyl group having 3 to 20 carbon atoms;
- R2 and R2′ are each hydrogen or a nitrogen protecting group;
- any one of X and Y is a vinyl or acetyl group, or a halogen atom, or an ethyl group substituted with a hydroxyl group, sulfide, selenide or a halogen atom while the other is a methyl group;
- and any one of X′ and Y′ is a vinyl or acetyl group, or a halogen atom, or an ethyl group substituted with a hydroxyl group, sulfide, selenide or a halogen atom while the other is a methyl group.
2 more elements
Dependencies are inferred from the claim text.