High purity nitric oxide releasing compounds and methods of preparing same

A method of manufacturing a high purity nitric oxide releasing compound product preparation, comprising:

• preparing in a vessel a reaction mixture comprising a hydroxide or a hydroxide donor and one or more reaction mixture solvents;
• introducing nitric oxide into the vessel under an inert atmosphere to obtain a suspension comprising a nitric oxide releasing compound;
• filtering the suspension to obtain a nitric oxide releasing compound solid;
• dissolving the nitric oxide releasing compound solid in an aqueous solution to form a dissolved nitric oxide releasing compound solution;
• recrystallizing the nitric oxide releasing compound solid from the dissolved nitric oxide releasing compound solution to form a recrystallized nitric oxide releasing compound product, wherein the recrystallizing comprises a step of adding methanol to the dissolved nitric oxide releasing compound solution;
• filtering the recrystallized nitric oxide releasing compound product and washing the filtered recrystallized nitric oxide releasing compound product with a mixture of washing solvents to form a washed nitric oxide releasing compound product, wherein the mixture of washing solvents comprises methanol and one or more additional alcohols;
• drying the washed nitric oxide releasing compound product to form a dried nitric oxide releasing compound product;
• and
• dissolving the dried nitric oxide releasing compound product in water to form the high purity nitric oxide releasing compound product preparation.