Bicyclic compounds as inactivators of oat and gaba-at
AssigneeNorthwestern University
InventorsAllison Nicole Devitt, Richard Bruce Silverman
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Abstract
Disclosed are bicyclic compounds for use as inhibitors of aminotransferases such as gamma-aminobutyric acid amino-transferase (GABA-AT) and/or ornithine aminotransferase (OAT). The disclosed bicyclic compounds and the compositions containing the same may be used for treating diseases and disorders associated with GABA-AT and/or OAT activity, such as neurological and/or cell proliferative diseases or disorders.
Claims24
A compound of the following formula or a dissociated form, a non-protonated form, a zwitterion form, or a salt thereof:
- wherein R1 and R2 are independently hydrogen or halo, providing at least one of R1 and R2 is halo.
The method of claim 15 or 16, wherein the OAT is human ornithine aminotransferase (hOAT).
Dependencies are inferred from the claim text.