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US 2026/0265170 A1Published application
Methods and intermediates for preparing compounds
AssigneeViiV HEALTHCARE UK (NO.5) LIMITED
InventorsBenedict James BARRON, Sabine FENNER, Stuart Grahame LEACH, Matthew Allen ZAJAC
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Abstract
The disclosure relates to a process for the preparation of intermediates useful for preparing compounds that inhibit functions of the human immunodeficiency virus (HIV) during the virus replication cycle, such as disrupting functions of the capsid shell of HIV.
Claims20
A process for preparing a mixture comprising a compound of formula (I-a)
- and a compound of formula (I-b)
- comprising combining:
- (a) a compound of formula (II),
- (b) a compound of formula (III),
- wherein X is cyclopropyl, difluoromethyl, or trifluoromethyl and Y is a leaving group;
- (c) a chiral amine;
- (d) a lithium base;
- (e) optionally, a lithium salt;
- and
- (f) an aprotic solvent;
- to provide the mixture.
8 more elements
Dependencies are inferred from the claim text.