Liquid handling device
AssigneeOsler Diagnostics Limited
InventorsBarry Lillis, Steven Green, Vincent Linden, Konstantinos Psarros
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Abstract
The present disclosure relates to a liquid handling device, methods of operating a liquid handling device, a method of performing a diagnostic test, a computer program and a system. In particular, the liquid handling device is capable of controllable bi-directional or multi-directional flow of reagents across one or more reaction zones allowing rapid, precise and controllable quenching of reactions and/or biological interactions.
Claims10
A liquid handling device comprising:
- a sample chamber for receiving a sample;
- a measurement chamber for performing one or more measurements on the sample wherein the measurement chamber comprises a reaction zone and a plurality of electrodes;
- a first liquid reagent chamber;
- a sample chamber conduit which fluidically connects the sample chamber to the measurement chamber;
- a sample chamber conduit valve for opening and closing the sample chamber conduit;
- a first liquid reagent chamber conduit which fluidically connects the first liquid reagent chamber to the measurement chamber in an alternate flow direction to the sample chamber conduit;
- and
- a first liquid reagent chamber conduit valve for opening and closing the first liquid reagent chamber conduit.
A method of performing a diagnostic assay comprising sequentially moving a sample liquid from a sample chamber to a measurement chamber and moving a first and second liquid reagent into the measurement chamber, the method including:
- filling the sample chamber with the sample liquid;
- moving the sample liquid from the sample chamber to the measurement chamber;
- moving the second liquid reagent from a second liquid reagent chamber into the measurement chamber in the same flow direction as the sample liquid;
- and
- moving the first liquid reagent from a first liquid reagent chamber into the measurement chamber in an alternate flow direction to the sample liquid and performing a measurement,
- wherein the second liquid reagent is removed from the measurement chamber before the measurement is taken.
Dependencies are inferred from the claim text.