Enforced Tissue Residency of Payload Molecules By Acoustic Disruption

Abstract

A system (100) for controlling drug delivery through a tissue barrier includes an ultrasound transducer (104) and a controller (108). The ultrasound transducer is for sonicating a target volume to cause disruption of the tissue barrier and thereby increase a permeability thereof. The controller is configured to receive a specification of a target molecule, where the specification includes a pharmacokinetic parameter of the target molecule or a molecular size of the target molecule. The controller is also configured to operate the ultrasound transducer in accordance with the specification to permit passage of the target molecule through the tissue barrier in a manner that traps a target fraction of the target molecule behind the tissue barrier for a predetermined time period.

Dependencies are inferred from the claim text.