Inhibition of myc using high-density brush polymers

Abstract

Disclosed are protein-like polymers and uses thereof. In an aspect, the invention provides brush protein-like polymers that address challenges associated with conventional administration of free therapeutic peptides. The protein-like polymers generally comprise a polymer of formula (FX1). The polymer of formula (FX1) in some aspects comprises a peptide having similarity or homology to a Myc binding peptide sequence. The brush protein-like polymers of the invention include high-density brush polymers including brush block polymers and brush statistical polymers. In an embodiment, brush protein-like polymers of the invention exhibit proteolysis-resistant characteristics and maintain their biological function during formulation and administration.

Dependencies are inferred from the claim text.