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US 2026/0263552 A1Published application
Pharmaceutical compositions for improving oral bioavailability
AssigneeBristol-Myers Squibb Company
InventorsBo LANG, David John GOOD, Neil Raymond MATHIAS, Divyakant S. DESAI, Monika LAVAN, Freddy ARCE, Stephen M. CARL, Olafur S. GUDMUNDSSON, Kimberly Ann FOSTER
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Abstract
In accordance with the present disclosure, pharmaceutical formulations that improve the oral bioavailability of cyclic peptides, have been discovered.
Claims29
A pharmaceutical composition comprising:
- a cyclic peptide;
- and
- a decanoic acid salt.
A pharmaceutical composition comprising:
- a. Compound (I) having the formula:
- or a pharmaceutically acceptable salt thereof;
- b. about 27.5 wt % sodium decanoate;
- c. about 37 wt % to about 43 wt % microcrystalline cellulose;
- d. about 18 wt % to about 22 wt % mannitol;
- e. about 4 wt % croscarmellose sodium;
- f. about 2 wt % silicon dioxide;
- and
- g. about 2 wt % magnesium stearate.
6 more elements
A method of improving bioavailability of a cyclic peptide in a subject in need thereof comprising formulating the cyclic peptide with sodium decanoate.
Dependencies are inferred from the claim text.