Engineered immune cells expressing anti-u5 snrnp200 antibodies and uses thereof

An engineered immune cell including a receptor that comprises a U5 snRNP200 antigen binding fragment comprising:

• a VHCDR1 sequence, a VHCDR2 sequence, and a VHCDR3 sequence of
• GYYWS (SEQ ID NO:
• 17), EINHSGSTNYNPSLKS (SEQ ID NO:
• 18), and GRSTSPLDYYYYYMDV (SEQ ID NO:
• 19);
• or
• GYYWS (SEQ ID NO:
• 23), EINHSGSTNYNPSLKS (SEQ ID NO:
• 24), and GPRGMYSSSSGDY (SEQ ID NO:
• 25);
• or
• TYGMH (SEQ ID NO:
• 29), VIWYDGSNTYYADSVKG (SEQ ID NO:
• 30), and ARGRGYSAQGNRNRAYYFDY (SEQ ID NO:
• 31) respectively;
• and/or
• a VLCDR1 sequence, a VLCDR2 sequence, and a VLCDR3 sequence of:
• QGDFLRSYYAS (SEQ ID NO:
• 20), GKNKRPS (SEQ ID NO:
• 21), and NSRDRSGNHLV (SEQ ID NO:
• 22);
• or
• RASQGIRNDLG (SEQ ID NO:
• 26), AAVSLQS (SEQ ID NO:
• 27), and LOHNSYPRT (SEQ ID NO:
• 28);
• or
• RASQSVSSNLA (SEQ ID NO:
• 32), GAFTRVT (SEQ ID NO:
• 33), and QQYNDRPPYT (SEQ ID NO:
• 34), respectively, and/or
• a nucleic acid encoding the receptor, wherein the receptor is a T cell receptor or a chimeric antigen receptor.