Low dose therapeutic supplement to modulate cytokines

A process of preparing the pharmaceutical or therapeutic supplement composition of claim 9 comprising a pentacyclic triterpenoid, wherein the process comprises:

• a) blending the pentacyclic triterpenoid, and a water-soluble polymer having a glass transition temperature lower than 170° C. to obtain a mixture;
• b) melt extruding the mixture at a temperature from about 60° C. to about 180° C. to obtain an extrudate;
• c) grinding the extrudate to obtain a ground extrudate comprising a solid dispersion of an amorphous form of the pentacyclic triterpenoid;
• and
• d) formulating the solid dispersion to obtain the pharmaceutical or therapeutic supplement composition.