Indolinyl compound for treatment of viral infections unresponsive to treatment with a first antiviral therapy
OwnerAlexandre MERCIER, Varsha Varijakshan NAIR +4inventors
InventorsAlexandre MERCIER, Varsha Varijakshan NAIR, Roberto MATEO FERNANDEZ, Lindsey A. MAY, Pui Yan HO, Christopher M. RICHARDS
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Abstract
The present disclosure provides methods and pharmaceutical formulations for the treatment and prophylaxis of a viral infection unresponsive to treatment with one or more first antiviral therapy using an indolinyl compound.
Claims29
A method for the treatment of an HSV infection in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of Compound 1:
- or a pharmaceutically acceptable salt thereof;
- wherein the virus is unresponsive to treatment with one or more first antiviral therapy.
A method for the treatment of a viral infection unresponsive to treatment with one or more first antiviral therapies in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising Compound 1:
- or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.
A method for the treatment of HSV infection previously treated with acyclovir, in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of Compound 1:
- or a pharmaceutically acceptable salt thereof.
A method for the treatment of HSV infection previously treated with pritelivir, in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of Compound 1:
- or a pharmaceutically acceptable salt thereof.
A method of treatment of an HSV infection previously treated with an antiviral therapy in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of Compound 1:
- or a pharmaceutically acceptable salt thereof;
- wherein the HSV virus comprises one or more mutations.
Dependencies are inferred from the claim text.