Inhibitors of ca 2+/calmodulin-dependent protein kinase ii (camkii) that do not inhibit long-term potentiation (ltp) induction and therapeutic uses thereof

Abstract

Embodiments of the instant disclosure relate to compositions and methods of making and using ATP-competitive Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) inhibitors for treating a health condition. In certain embodiments, the health condition includes, but is not limited to, a health condition concerning the brain, and targeting the brain with one or more ATP-competitive CaMKII inhibitor to prevent, ameliorate, or treat the health condition. In some embodiments, ATP competitive CaMKII inhibitors of use herein preserve, restore, or induce long-term potentiation (LTP) mechanisms in the subject. In some embodiments, the health condition includes a chronic health condition, and the treatment includes a prolonged treatment of a subject having such a chronic health condition.

Dependencies are inferred from the claim text.