US 2026/0263408 A1 · SUCCINYLCHOLINE CHLORIDE PREFILLED SYRINGE

Abstract

Prefilled syringes containing a succinylcholine chloride composition, where the prefilled syringes comprise a syringe barrel and a syringe tip comprising cyclic olefin monopolymer (“COP”) or cyclic olefin copolymer (“COC”). The syringes can also comprise a luer adapter integral with the syringe tip, where the syringe barrel, syringe tip and luer adapter are a single element comprising COP or COC. The succinylcholine chloride compositions include succinylcholine chloride, a tonicity agent and one or more pH adjusters in an aqueous solution having a pH from about 3.0-4.5. The prefilled syringes containing the succinylcholine compositions are storage-stable for extended periods of time at a temperature of 2-8° C., have acceptable physical parameters such as glide force and break force, and make safe and robust connections with needles and needleless luer adapter devices (“NLADs”).

Claims14

Dependent claims

A prefilled syringe containing a premixed succinylcholine chloride composition,

wherein the succinylcholine chloride composition comprises (a) about 10 mg/ml to about 30 mg/ml succinylcholine chloride;
(b) a tonicity agent comprising sodium chloride, (c) a pH adjuster comprising hydrochloric acid, sodium hydroxide, or a combination thereof, and (d) water for injection;
wherein the succinylcholine chloride composition has an initial pH of from about 3.0 to about 4.5;
wherein the syringe has a syringe barrel and a syringe tip comprising COP or COC, a plastic plunger rod, and a plunger rod stopper comprising bromobutyl rubber, chlorobutyl rubber, or an elastomer coated with an ETFE film;
and
wherein the succinylcholine chloride composition in the prefilled syringe contains at least 90% of the initial amount of succinylcholine chloride after storage at 2-8° C. for up to 15 months, as determined by HPLC.

3 more elements

Dependencies are inferred from the claim text.

Succinylcholine chloride prefilled syringe

Life of this patent

Succinylcholine chloride prefilled syringe

Life of this patent

Abstract

Claims14