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US 2026/0263403 A1Published application
Compositions and methods for treating traumatic brain injury
AssigneeThe Children's Hospital of Philadelphia
InventorAkiva S. Cohen
Life of this patent
Estimating the term…
Abstract
Compositions and methods are provided for the treatment of pathologies associated with traumatic brain injury.
Claims23
1:
- A method for reducing a pathology associated with traumatic brain injury in a subject in need thereof, said method comprising administering to said subject at least one branched chain amino acid.
2:
- The method of claim 1, wherein said traumatic brain injury is an acute, mild traumatic brain injury.
3:
- The method of claim 1, wherein said traumatic brain injury is a concussion.
4:
- The method of claim 1, wherein said method comprises administering valine, leucine, and isoleucine to said subject.
5:
- The method of claim 1, wherein said branched chain amino acid is in a composition with at least one pharmaceutically acceptable carrier.
6:
- The method of claim 1, wherein said subject is less than 35 years of age.
7:
- The method of claim 1, wherein said pathology is a headache.
8:
- The method of claim 1, wherein said pathology is reduced physical activity.
9:
- The method of claim 1, wherein said pathology is reduced sleep efficiency and/or sleep time.
10:
- The method of claim 1, further comprising administering acetate to said subject.
11:
- The method of claim 1, wherein said branched chain amino acids are administered orally.
12:
- The method of claim 1, wherein said method comprises administering to said subject a composition comprising valine, leucine, isoleucine, a flavor masking agent, a sweetener, and a flavoring agent.
(canceled)
14:
- The method of claim 12, wherein said flavor masking agent is a gluconate salt.
15:
- The method of claim 12, wherein said sweetener is sucralose.
16:
- The method of claim 1, wherein said branched chain amino acid is administered for at least 10 consecutive days.
17:
- The method of claim 1, wherein said method comprises administering at least about 50 g of valine, leucine, and isoleucine per day.
18:
- The method of claim 12, wherein said composition comprises valine, leucine, isoleucine, a flavor masking agent, and a sweetener in a ratio of about 1:1:1:1.3:0.9.
19:
- The method of claim 12, further comprising administering acetate to said subject.
(canceled)
21:
- A method for treating a headache in a subject in need thereof, said method comprising administering to said subject at least one branched chain amino acid, wherein said subject has a traumatic brain injury.
22-38. (canceled)
39:
- The method of claim 21, wherein the duration, severity, and/or presence of the headache is reduced.
Dependencies are inferred from the claim text.