Lutein and 1,3-dioleoyl-2-palmitoyl glycerol for use in the prevention or treatment of a disorder of the gastrointestinal tract
AssigneeN.V. Nutricia
InventorsIngrid Brunhilde Renes, Jan Knol, Noortje IJssennagger, Xianfeng Zhao
Life of this patent
Estimating the term…
Abstract
The present invention relates to the combination of lutein and 1,3-dioleoyl-2-palmitoylglycerol.
Claims17
A combination of lutein and 1,3-dioleoyl-2-palmitoyl glycerol (OPO) for use in the prevention or treatment of a disorder of the gastrointestinal tract in a human subject, wherein the disorder of the gastrointestinal tract is caused by compromised lactase expression in the gastro-intestinal tract.
The combination for use according to any one of the preceding claims, wherein the treatment of the disorder of the gastrointestinal tract is by increasing the expression of lactase in the gastro-intestinal tract.
The combination for use according to any one of the preceding claims, wherein the combination further consists ofnon-digestible oligosaccharides selected from galacto-oligosaccharides (GOS), fructo-oligosaccharides (FOS), human milk oligosaccharides (HMO) or combinations thereof.
The combination for use according to any one of the preceding claims, wherein the combination is comprised in a composition further comprising 10-65 g lactose per 100 g dry weight of the composition.
The combination for use according to any one of the preceding claims, wherein the compromised lactase expression is due to lactase non-persistence, being born preterm, coeliac disease, inflammatory bowel disease, short bowel syndrome, intestinal infection, exposure of the subject to chemotherapy, or combinations thereof.
The combination for use according to any one of the preceding claims, wherein symptoms of the disorder of the gastrointestinal tract are selected from diarrhea, constipation, flatulence, bloating, abdominal pain or combinations thereof.
The combination for use according to any one of the preceding claims, wherein the combination is comprised in an oral nutritional composition and wherein the composition comprises digestible carbohydrates, lipids, proteins and an energy content of at least 400 kcal per 100 g based on dry weight of the composition, wherein the composition comprises, per 100 g based on dry weight of the composition:
- a. 30-500 μg lutein;
- b. 0.5-10 g non-digestible oligosaccharides comprising fructo-oligosaccharides, galacto-oligosaccharides and human milk oligosaccharides;
- and
- c. 2-10 g g 1,3-dioleoyl-2-palmitoyl glycerol.
Dependencies are inferred from the claim text.