Amphiphilic nanoparticles to target amyloid beta-induced microglial activation
AssigneesRutgers, The State University of New Jersey, The Regents of the University of California
InventorsHoda M. Gebril, Prabhas V. Moghe, Kathryn E. Uhrich
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Abstract
Nanoparticle compositions and methods inhibiting amyloid beta (Aβ) fibrilization in a subject in need thereof using nanoparticles to target fibril β-amyloid (fAβ)-specific scavenger receptors. Also provided is a method of using nanoparticle compositions to treat Alzheimer's disease (AD) and similar amyloidopathies.
Claims20
A method of inhibiting amyloid beta (Aβ) fibrilization in a subject in need thereof, comprising administering a nanoparticle to the subject, wherein the nanoparticle comprises a hydrophobic core and a bioactive amphiphilic macromolecule that forms a shell coating the hydrophobic core, and
- wherein the bioactive amphiphilic macromolecule comprises a structure set forth in Formula A or Formula B:
- wherein n is an integer from 100 to 125;
- and
- wherein z is an integer from 2 to 20.
A method of treating Alzheimer's disease (AD) in a subject in need thereof, comprising administering a nanoparticle to the subject, wherein the nanoparticle comprises a hydrophobic core and a bioactive amphiphilic macromolecule coating the core, and wherein the bioactive amphiphilic macromolecule comprises a structure set forth in Formula A or Formula B:
- wherein n is an integer from 100 to 125;
- and
- wherein z is an integer from 2 to 20.
A nanoparticle comprising a hydrophobic core and a bioactive amphiphilic macromolecule coating the core, and
- wherein the bioactive amphiphilic macromolecule comprises a structure set forth in Formula A or Formula B:
- wherein n is an integer from 100 to 125;
- and
- wherein z is an integer from 2 to 20.
Dependencies are inferred from the claim text.