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US 2026/0263369 A1Published application
Methods and compositions for treating cancer using exosomes-associated gene editing
AssigneeBoard of Regents, The University of Texas System
InventorsRaghu KALLURI, Valerie LEBLEU, Fei XIAO
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Abstract
Provided herein are compositions comprising exosomes comprising CD47 on their surface, and further comprising a CRISPR system. Further provided are methods of using the exosomes for gene editing and the treatment of cancer by gene editing.
Claims21
1-93. (canceled)
A method of inhibiting progression from a pancreatic neoplasm to pancreatic ductal adenocarcinoma (PDAC) in a patient, the method comprising systemically administering to the patient a composition comprising exosomes,
- wherein the exosomes:
- express CD47 on their surface;
- and
- comprise a CRISPR system that edits cancer cells having a KrasG12D mutation, and
- wherein administration of the composition inhibits progression of the pancreatic neoplasm to invasive or metastatic PDAC in the patient.
2 more elements
Dependencies are inferred from the claim text.