Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof
AssigneeHalozyme Hypercon, Inc.
InventorsChase Spenser Coffman, Lyndon Fitzgerald Charles, JR., Paul Brown, Daniel Benjamin Dadon, Lisa Liu, Cory Robinson
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Abstract
The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.
Claims21
1-20. (canceled)
A composition comprising particles comprising one or more therapeutic or diagnostic agents and an excipient, wherein at least a portion of the excipient is crystallized and localized at the particle surface, and wherein the particles are formed from atomization.
A method of administering a therapeutic or diagnostic agent to a mammal, the method comprising administering an effective amount of a pharmaceutical composition to the mammal, wherein the pharmaceutical composition comprises particles comprising the therapeutic or diagnostic agent and an excipient, wherein at least a portion of the excipient is crystallized and localized at the particle surface, and wherein the particles are formed from atomization.
Dependencies are inferred from the claim text.