Prosthetic capsular devices, systems and methods for drug delivery

A system for intraocular drug delivery, comprising:

• a prosthetic capsular device configured to be inserted into a natural capsular bag of an eye after removal of a lens, the prosthetic capsular device comprising a housing structure having an anterior portion with an anterior opening, a posterior portion with a posterior opening, and a lateral portion interposed between the anterior portion and the posterior portion, the anterior portion, posterior portion, and lateral portion together defining an internal cavity;
• and
• a drug delivery capsule configured to be received within the internal cavity of the prosthetic capsular device, the drug delivery capsule comprising a posterior surface and an anterior surface meeting at an outer end of the capsule, an interior surface having a shape of a section of a radial surface of a cylinder and being concave, a radial surface extending from an inner end to the outer end of the capsule, an inner cavity configured to receive a drug, one or more diffusion openings extending from an exterior surface of the capsule to the inner cavity and configured to permit the drug to elute from the inner cavity into the interior of the prosthetic capsular device, and a slit extending from the exterior surface of the capsule to the inner cavity and configured to permit introduction of the drug into the inner cavity,
• wherein the drug delivery capsule is sized and shaped such that the concave interior surface of the capsule conforms at least in part to an interior surface of the housing structure when the capsule is disposed within the internal cavity, and wherein the prosthetic capsular device and the drug delivery capsule together are configured to position the drug in a location peripherally of a visual axis of the eye and to dispense the drug from within the natural capsular bag over an extended period of time.