Thrombus removal systems and associated methods

A system for removing thrombus, the system comprising:

• an elongated catheter having at least one aspiration lumen configured to remove thrombus material;
• an aspiration mechanism fluidly coupled to the aspiration lumen and configured to reduce pressure in the aspiration lumen;
• a valve coupled to the aspiration mechanism, the valve having a valve state that comprises an open state or a closed state;
• a first pressure sensor disposed distal to the valve and configured to monitor a first pressure inside the aspiration lumen;
• a second pressure sensor disposed proximal to the valve and configured to monitor a second pressure inside the aspiration lumen;
• and
• an electronic controller operatively coupled to the pressure sensor and the valve, the electronic controller being configured to open and close the valve and monitor the first pressure and second pressure within the aspiration lumen to determine if a clot is engaged with the elongated catheter or if the clot has been at least partially removed.