Method and system to non-invasively assess elevated pulmonary capillary wedge pressure

A method to non-invasively estimate the presence of elevated pulmonary capillary wedge pressure (PCWP) in a mammalian subject, the method comprising:

• obtaining, by one or more processors, a first biophysical signal data set associated with a first photoplethysmographic signal and a second photoplethysmographic signal, wherein the first biophysical data set has been acquired over multiple cardiac cycles of the subject;
• obtaining, by the one or more processors, a second biophysical signal data set associated with a cardiac signal, wherein the second biophysical data set has been simultaneously acquired with the first biophysical signal data set over the multiple cardiac cycles;
• determining, by the one or more processors utilizing at least a portion of the first and second biophysical signal data sets, a plurality of values associated with a plurality of features;
• and
• determining, by the one or more processors, an estimated value for the presence of elevated pulmonary capillary wedge pressure,
• wherein the estimated value for the presence of abnormal pulmonary capillary wedge pressure is outputted for use in a diagnosis of expected heart failure (HF) or to direct treatment of the expected heart failure.