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AssigneeDaegu Gyeongbuk Institute of Science and Technology
InventorsJong Hyuk YOON, Yeon Suk JO, Geun A PARK, Sung Won BAE, Yang Woo KWON, Seul Ah LEE, Kuk In JANG, Chan Y LEE, Yong Seok OH, Ha Gyeong LEE, Da Young KWON
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The present invention relates to a biomarker for the early diagnosis of Alzheimer's disease and a use thereof, and more particularly, the present invention relates to: a biomarker composition for the early diagnosis of Alzheimer's disease, the biomarker composition comprising one or more genes selected from the group consisting of alpha-2-macroglobulin (A2M), creatine kinase M-type (CKM), filamin-A (FLNA), integral alpha-IIb (ITGA2B), alpha-1-acid glycoprotein 2 (ORM2), phospholipid transfer protein (PLTP), haptoglobin (HP), sulfhydryl oxidase 1 (QSOX1), protein-glutamine gamma-glutamyltransferase 2 (TGM2), filamin C (FLNC), heat shock protein 70 (HSP70) and lysomal alpha-mannosidase (MAN2B1), or a protein expressed from the genes; a method for the early diagnosis of Alzheimer's disease; a diagnostic kit for the early diagnosis of Alzheimer's disease; and a method for providing information for predicting and diagnosing Alzheimer's disease.
A biomarker composition for diagnosing early-stage Alzheimer's disease, the composition comprising at least one gene selected from the group consisting of A2M (alpha-2-macroglobulin), CKM (creatine kinase M-type), FLNA (filamin-A), ITGA2B (Integrin alpha-IIb), ORM2 (alpha-1-acid glycoprotein 2), PLTP (phospholipid transfer protein), HP (haptoglobin), QSOX1 (sulfhydryl oxidase 1), TGM2 (protein-glutamine gamma-glutamyltransferase 2), FLNC (filamin C), HSP70 (heat shock protein 70), and MAN2B1 (lysosomal alpha-mannosidase), or a protein expressed from the gene.
A composition for early Alzheimer's disease diagnosis, the composition comprising a substance for measuring mRNA or protein level of at least one gene selected from the group consisting of A2M(alpha-2-macroglobulin), CKM(creatine kinase M-type), FLNA(filamin-A), ITGA2B(Integrin alpha-IIb), ORM2(alpha-1-acid glycoprotein 2), PLTP(phospholipid transfer protein), HP(haptoglobin), QSOX1(sulfhydryl oxidase 1), TGM2(protein-glutamine gamma-glutamyltransferase 2), FLNC(filamin C), HSP70(heat shock protein 70), and MAN2B1(lysosomal alpha-mannosidase).
A method for providing information for predicting and diagnosing Alzheimer's disease, the method comprising the steps of:
Dependencies are inferred from the claim text.