Bacteriophage(s) targeting capsular deficient klebsiella pneumoniae (kp), compositions comprising it(them) and use(s) thereof

Abstract

The invention relates to a bacteriophage targeting capsular-deficient Klebsiella pneumoniae (Kp), comprising particular tail fiber polypeptides, which is capable of infecting at least two capsular-deficient Klebsiella pneumoniae of distinct O-types, in particular at least three distinct O-types of capsular-deficient Klebsiella pneumoniae. The invention also relates to a pharmaceutical composition comprising the same, a nucleic acid molecule having at least 99% of identity with the genomic sequence of the said bacteriophage, and the use of the said bacteriophage or composition(s) as a medicament, especially against an infection caused by at least one type of Klebsiella pneumoniae (Kp). The invention also relates to a method for decreasing the bacterial load of at least one Klebsiella pneumoniae (Kp) strain in the environment, making use of said bacteriophage.

Dependencies are inferred from the claim text.