Extracellular Vesicles (EVs) Derived from Mesenchymal Stromal Cells and Method for Obtaining Said EVs
AssigneeExo Biologics SA
InventorMarcin JURGA
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Abstract
The current invention relates to a process for the manufacturing of a composition of extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs), said method comprises: culturing and expanding MSCs in a serum-free and xeno-free medium comprising purified human serum albumin and human transferrin; collecting cell supernatant, said cell supernatant comprises EVs; filtering said cell supernatant to obtain EVs; and concentrating said EVs, preferably by means of ultrafiltration. In a second and further aspect, said invention is directed to compositions comprising EVs and their clinical use.
Claims14
A method of prevention or treatment of a disease or disorder in a patient in need thereof, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising Extracellular Vesicles (EVs) derived from mesenchymal stromal cells (MSCs), wherein said EVs have a particle size between 0.05 and 0.22 μm, and wherein said composition has a human albumin concentration of between 10 and 30 g/l, and wherein at least 90% of said human albumin present in said composition is associated with said EVs.
Dependencies are inferred from the claim text.