Therapy

A method of treatment of a haematological disorder, immune disorder, metabolic disorder, or neurodegenerative disorder, the method comprising the steps of:

• i) obtaining an isolated population of HSPC;
• ii) culturing the isolated population of HSPC for at least 48 hours to form a first cultured population;
• iii) adding a histone deacetylase inhibitor (HDAC inhibitor), and further culturing the cells to form a second cultured population;
• iv) adding an aminothiol compound to the second cultured population and further culturing the cells to form an expanded population of cells, wherein the aminothiol compound has the formula
• RNH(CnH2n)NH(CnH2n)SX, wherein R is hydrogen, an aryl, an acyl, or an alkyl group containing from 1 to 7 carbon atoms, each n has a value of from 2 to 6 and X is H or PO3H2;
• or a pharmaceutically acceptable salt thereof;
• and
• v) administering the expanded population of cells to a subject.