Engineered natural killer cells with enhanced antitumor memory responses
AssigneeBoard of Regents, The University of Texas System
InventorsKaty REZVANI, Mayra SHANLEY, Ken CHEN, Merve DEDE, Vakul MOHANTY, Jinzhuang DOU
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Abstract
Embodiments of the disclosure include methods and compositions in which engineered NK cells are modified by the hand of man to overexpress a CCAAT/enhancer binding protein (C/EBP) family member. Such engineered NK cells have improved antitumor immune memory-like features, increased long term cytotoxicity, and metabolic fitness in vivo and in vitro.
Claims79
An engineered Natural Killer (NK) cell modified to overexpress a CCAAT/Enhancer-binding protein (CEBP) transcription factor family protein.
A method of treating a disease in an individual, the method comprising the step of administering to the individual a therapeutically effective amount of any one of the engineered NK cells or compositions of any one of the preceding claims.
An isolated nucleic acid encoding a CEBP protein fused to a heterologous transcriptional regulatory element.
A method of treating glioblastoma, the method comprising administering to an individual a therapeutically effective amount of an NK cell engineered to autonomously and/or constitutively express secreted IL-21.
Dependencies are inferred from the claim text.