Compositions and methods for reducing off-target toxicity of antibody drug conjugates
AssigneeThe Research Foundation for The State University of New York
InventorsJoseph P. BALTHASAR, Brandon M. BORDEAU, Toan Duc NGUYEN, Joseph Ryan POLLI
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Abstract
Provided are compositions and methods for reducing off-target toxicity of antibody-drug conjugates (ADCs). The compositions comprise an ADC, and an agent targeted to the drug (payload) that is delivered by or derived from the ADC. The ADC and the agent targeted to the payload may be delivered together or separately in the treatment of various conditions (such as tumors) by ADCs. Examples of agents targeted to payload include antibodies, fragments, or modifications thereof.
Claims13
A method for reducing non-target toxicity of an antibody-drug conjugate (ADC) comprising administering to an individual in need of treatment the ADC and a payload binding agent (PBA) which specifically binds to the drug of the ADC.
Dependencies are inferred from the claim text.