Anti-mesothelin antibodies and uses thereof
AssigneePhanes Therapeutics, Inc.
InventorsHuiwen Wu, Jack Chongyang Li, Haiqun Jia, Hui Zou
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Abstract
Anti-mesothelin antibodies and antigen-binding fragments thereof and chimeric antigen receptors (CARs) comprising anti-mesothelin antigen-binding domains are described. Also described are nucleic acids encoding the antibodies and CARs, compositions comprising the antibodies and CARs, and methods of producing the antibodies and CARs, and methods of using the antibodies and CARs for treating or preventing diseases such as cancer and/or an inflammatory' disease, and/or autoimmune disease.
Claims20
An isolated monoclonal antibody or antigen-binding fragment thereof or an antigen-binding domain comprising a heavy chain variable region comprising a heavy chain complementarity determining region 1 (HCDR1), HCDR2, HCDR3, and a light chain variable region comprising a light chain complementarity determining region 1 (LCDR1), LCDR2, and LCDR3, having the polypeptide sequences of:
- (1) SEQ ID NOs:
- 3, 4, 5, 6, 7, and 8, respectively, or SEQ ID NOs:
- 9, 10, 11, 12, 13, and 14, respectively;
- (2) SEQ ID NOs:
- 17, 18, 19, 20, 21, and 22, respectively, or SEQ ID NOs:
- 23, 24, 25, 26, 27, and 28, respectively;
- (3) SEQ ID NOs:
- 31, 32, 33, 34, 35, and 36, respectively or SEQ ID NOs:
- 37, 38, 39, 40, 41, and 42, respectively;
- or
- (4) SEQ ID NOs:
- 60, 61, 62, 63, 64, and 65, respectively, or SEQ ID NOs:
- 66, 67, 68, 69, 70, and 71, respectively;
- wherein the antibody or antigen-binding fragment or the antigen-binding domain thereof specifically binds mesothelin, preferably human mesothelin.
Dependencies are inferred from the claim text.