Anti-cd25 antigen-binding proteins and uses thereof
AssigneeOdyssey Therapeutics, Inc.
InventorsLuigi FRANCHI, Anthony W. OPIPARI, Laura PREISS, Ferdinand HUBER, Paul-Albert KÖNIG, Annegrit SEIFRIED
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Abstract
The present application provides antigen-binding proteins (e.g., antibodies such as single-domain antibodies) that specifically bind duster of differentiation 25 (CD25). The application also provides fusion proteins and conjugates comprising the antigen-binding proteins, polynucleotides and recombinant vectors encoding the antigen-binding proteins, as well as host cells and methods for preparing the antigen-binding proteins. The application further provides pharmaceutical compositions comprising the antigen-binding proteins.
Claims84
An antigen-binding protein that specifically binds cluster of differentiation 25 (CD25), comprising a complementarity determining region 3 (CDR3) comprising an amino acid sequence selected from
- (SEQ ID NO:
- 31)
- a). NAL(G/L/P/Q/W)Y;
- (SEQ ID NO:
- 34)
- b). NALR(D/H/N/F);
- (SEQ ID NO:
- 36)
- c). (K/S/T)TLRY;
- (SEQ ID NO:
- 5119)
- d). (A/V/S)(K/T)G(R/A/K)(G/H/N/R)SG(S/G)YYP(W/F/L)
- D(D/E)(Y/V);
- (SEQ ID NO:
- 5208)
- e). AA(S/T)(D/N/Y/K)(F/V)(L/P)(I/L)A(T/I/A)(T/S/A)
- IS(A/G)(Y/H)DY;
- (SEQ ID NO:
- 2263)
- f). AAYVYPDYYCS(D/E)YVLL(K/R)YDY;
- (SEQ ID NO:
- 2265)
- g). NIYR(P/S)QVP(P/S/T)TRYS;
- and
- (SEQ ID NO:
- 4323)
- h). AAKRLGP(M/I/A/L)VH(Q/R)YSLEVLTPLFLDEYDY.
The antigen-binding protein of claim 2, wherein the CDR3 comprises an amino acid sequence selected from SEQ ID NOs:
- 3, 7, 11, 15, 19, 39, 41, 1237, 1239, 1271, 1275, 1298, 1301, 1331, 1415, 1419, 1421, 1428, 1432, 1442, 1444, 1445, 1447, 1448, 2244, 2247, 2249, 2250, 2267, 4311-4316, 4336, 4340, 4787, 4866, 4875, 4878, 4879, and 4880.
An antigen-binding protein that specifically binds cluster of differentiation 25 (CD25), comprising a CDR1 comprising an amino acid sequence selected from any one of SEQ ID NOs:
- 626-930, 2831-3126, and 4560-4670;
- a CDR2 comprising an amino acid sequence selected from any one of SEQ ID NOs:
- 931-1235, 3127-3422, and 4671-4780;
- and/or a CDR3 comprising an amino acid sequence selected from any one of SEQ ID Nos:
- 1236-1540, 3423-3718, and 4781-4891.
Dependencies are inferred from the claim text.