Luminescent metal binding proteins and peptides for use in microscopy
AssigneesPhoton Biosciences, LLC, Montana State University
InventorsKevin Lewis, ChulHee Kang, James A. Brozik, Charles Martin Lawrence
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Abstract
Microscopy probes that include luminescent metal binding proteins and peptides and analogs thereof that are configured to be used in electron microscopy and methods of performing light and electron microscopy using the microscopy probes of the present technology.
Claims20
A microscopy probe comprising a luminescent metal binding protein, wherein:
- the microscopy probe is configured to be detected using a light microscope and an electron microscope;
- and
- the luminescent metal binding protein is configured to chelate a luminescent metal.
A method of correlated light and electron microscopy (CLEM) comprising detecting a microscopy probe using a light microscope and an electron microscope, wherein the microscopy probe comprises a luminescent metal binding protein that is configured to chelate a luminescent metal.
The method of any of claims 11-15, wherein the luminescent metal binding protein comprises more than 20% N and Q amino acids.
Dependencies are inferred from the claim text.