C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses

A compound of the formula:

• wherein:
• R1 is hydrogen, alkyl(C≤8), cycloalkyl(C≤8), substituted alkyl(C≤8), or substituted cycloalkyl(C≤8);
• R2 is —(CH2)m—(OCH2)n—R5, wherein:
• R5 is hydroxy or acyl(C≤8), alkoxy(C≤8), acyloxy(C≤8), alkylsilyloxy(C≤8), or a substituted version of any of these groups;
• m is 0, 1, 2, 3, or 4;
• and
• n is 0, 1, 2, or 3;
• R3 is hydrogen, hydroxy, or alkoxy(C≤8), acyloxy(C≤8), or substituted version of either of these groups;
• and
• Y is
• —NRaC(O)Re, wherein:
• Rd is hydrogen, alkyl(C≤8), or substituted alkyl(C≤8);
• Re is hydrogen, hydroxy, or amino;
• or
• alkyl(C≤8), cycloalkyl(C≤8), alkenyl(C≤8), alkynyl(C≤8), aryl(C≤8), aralkyl(C≤8), heteroaryl(C≤8), heterocycloalkyl(C≤8), alkoxy(C≤8), cycloalkoxy(C≤8), aryloxy(C≤8), aralkoxy(C≤8), heteroaryloxy(C≤8), acyloxy(C≤8), alkyl-amino(C≤8), dialkylamino(C≤8), arylamino(C≤8), or a substituted version of any of these groups;
• or a pharmaceutically acceptable salt thereof.