Tyrosine kinase inhibitors

A compound of Formula (IIB):

• or a pharmaceutically acceptable salt, deuterated form, or stereoisomer thereof;
• wherein:
• R1 is —H, halo, —CN, —C1-6 alkyl, —C1-6 alkenyl, —C1-6 alkynyl, —C3-6 cycloalkyl, —OH, —OC1-6 alkyl, —OC3-6 cycloalkyl, —Oheterocyclyl, —NH2, —NH(C1-6 alkyl), —N(C1-6 alkyl)2, —NH(C3-6 cycloalkyl), or —N(C1-6 alkyl)(C3-6 cycloalkyl);
• wherein the —C1-6 alkyl, —C1-6 alkenyl, —C1-6 alkynyl, —C3-6 cycloalkyl, —OC1-6 alkyl, —OC3-6 cycloalkyl, —Oheterocyclyl, —NH(C1-6 alkyl), —N(C1-6 alkyl)2, —NH(C3-6 cycloalkyl), or —N(C1-6 alkyl)(C3-6 cycloalkyl) are each independently optionally substituted with 1 or more halo, —CN, —OC1-6 alkyl, —OC1-6 haloalkyl, or -CO2alkyl;
• R2 is —H, halo, —CN, —C1-6 alkyl, —OC1-6 alkyl, —C1-6 alkenyl, —C1-6 alkynyl, —C3-6 cycloalkyl, or heterocyclyl;
• wherein the —C1-6 alkyl, —OC1-6 alkyl, —C1-6 alkenyl, —C1-6 alkynyl, —C3-6 cycloalkyl, or heterocyclyl are each independently optionally substituted with 1 or more halo, —CN, —OC1-6 alkyl, —OC1-6 haloalkyl, or —CO2alkyl;
• or R1 and R2 are taken together to form a carbocyclyl or saturated or partially unsaturated heterocyclyl, wherein the carbocyclyl or saturated or partially unsaturated heterocyclyl are each independently optionally substituted with 1 or more halo, —OC1-6 alkyl, —C1-6 alkyl, —C3-6 cycloalkyl, or —CN;
• wherein the —C1-6 alkyl or —C3-6 cycloalkyl, are each independently optionally substituted with 1 or more —CN, —OC1-6 alkyl, —OC1-6 haloalkyl, or —CO2alkyl;
• R3 is —H, halo, —C1-6 alkyl, —O—C1-6 alkyl, or —CN;
• wherein the —C1-6 alkyl or —OC1-6 alkyl, are each independently optionally substituted with 1 or more halo, —CN, —OC1-6 alkyl, —OC1-6 haloalkyl, or —CO2alkyl;
• each R4 is independently —H or -D;
• X1 is CH or N;
• X2 is C(R8)2 or NH;
• each R8 is independently H, halo, —C1-6 alkyl, —C1-6 haloalkyl, —O—C1-6 alkyl, or —CN;
• RYB, RYC, and RYD are each independently —H, —CN, halo, —NRARB, —C1-6 alkyl, —OC1-6 alkyl, —C1-6 alkenyl, —C1-6 alkynyl, —C3-6 cycloalkyl, heterocyclyl, or aryl, wherein the, —C1-6 alkyl, —OC1-6 alkyl, —C1-6 alkenyl, —C1-6 alkynyl, —C3-6 cycloalkyl, heterocyclyl, or aryl are each optionally substituted with halo, —C1-6 alkyl, —C1-6 haloalkyl, —OC1-6 alkyl, —OC3-6 cycloalkyl, or —CN;
• RA and RB are each independently —H, —C1-C6 alkyl, cycloalkyl, or heterocyclyl;
• and
• R5, R6 and R7 are each independently selected from the group consisting of —H, —CN, halo, —C1-6 alkyl, —C1-6 haloalkyl, —OC1-6 alkyl, or —OC3-6 cycloalkyl, or R6 and R7 are taken together to form a carbocyclyl.