Thiophene-2-carboxylic acid derivative, and preparation method therefor and medical use thereof

A thiophene-2-carboxylic acid derivative of general formula (I), and a tautomer thereof and a pharmaceutically acceptable salt thereof:

• wherein R1 is selected from COOR5;
• R2 is selected from H and halogen;
• R3 is selected from phenyl, pyridinyl, pyrazinyl, pyrimidinyl, and imidazolyl, wherein the phenyl, pyridinyl, pyrazinyl, pyrimidinyl, or imidazolyl is independently optionally substituted with 1 to 5 substituents selected from:
• C1-6 alkyl, halogen, cyano, carboxyl, acetyl, methanesulfonyl, C1-4 haloalkyl, C1-4 haloalkoxy, OH, C1-6 alkoxy, and dimethylamino;
• X is selected from O, S, and NH;
• R4 is selected from:
• wherein Ring is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyrrolyl, thienyl, furanyl, thiazolyl, isothiazolyl, imidazolyl, or pyrazolyl;
• R5 is H, C2-4 alkyl, C2-3 alkyl-C3-6 cycloalkyl, C2-3OOCCH3, C2-3OCNMe2, or C2-3 NMe2;
• R7 is H;
• R8 is selected from H, C1-6 alkyl, C3-6 cycloalkyl, CH2CONH2, CH2COMe2, CH2CH2OH, CH2CH2Me, (CH2)3OH, (CH3)3OMe, (CH2)4OH, (CH2)4OMe, (CH2)5OH, (CH2)2COOH, (CH2)3COOH, (CH2)4COOH, (CH2)5COOH, (CH2)2CH(CH3)COOH, C(CH2OH)3, C(CH2OH)2CH3, CH2CH(CH3)OH, (CH2)2CF3, (CH2)3CF3, (CH2)4CF3,
• R11 is selected from H, NO2, CN, OH, NH2, F, Cl, Br, I, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, COR8, CONR7R8, CO2R8, SO2NR7R8, and SO3R8.